Health care faces daunting challenges globally. The supply of health care services is constrained by the inefficiency of service models, workforce capacity, and the need for capital investments in critical infrastructure. Simultaneously, demand is growing through the transition from communicable to non-communicable diseases and the aging of populations. This article highlights examples of successful reverse innovations. We clarify the basis of their success by placing the cases within a health care framework that identifies the core purpose of the innovations and their alignment with six key environmental factors: Market structure; financing, consumers, policy; accountability metrics; and technology.